全文获取类型
收费全文 | 1333篇 |
免费 | 87篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 33篇 |
妇产科学 | 33篇 |
基础医学 | 137篇 |
口腔科学 | 23篇 |
临床医学 | 174篇 |
内科学 | 229篇 |
皮肤病学 | 17篇 |
神经病学 | 100篇 |
特种医学 | 92篇 |
外科学 | 223篇 |
综合类 | 25篇 |
一般理论 | 1篇 |
预防医学 | 77篇 |
眼科学 | 48篇 |
药学 | 135篇 |
中国医学 | 9篇 |
肿瘤学 | 55篇 |
出版年
2023年 | 16篇 |
2022年 | 12篇 |
2021年 | 37篇 |
2020年 | 44篇 |
2019年 | 66篇 |
2018年 | 69篇 |
2017年 | 49篇 |
2016年 | 52篇 |
2015年 | 46篇 |
2014年 | 61篇 |
2013年 | 96篇 |
2012年 | 99篇 |
2011年 | 110篇 |
2010年 | 76篇 |
2009年 | 74篇 |
2008年 | 78篇 |
2007年 | 53篇 |
2006年 | 50篇 |
2005年 | 48篇 |
2004年 | 50篇 |
2003年 | 42篇 |
2002年 | 38篇 |
2001年 | 26篇 |
2000年 | 18篇 |
1999年 | 7篇 |
1998年 | 5篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1995年 | 8篇 |
1993年 | 2篇 |
1992年 | 4篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 8篇 |
1988年 | 12篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 8篇 |
1984年 | 3篇 |
1983年 | 6篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1979年 | 7篇 |
1978年 | 2篇 |
1975年 | 4篇 |
1974年 | 2篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有1426条查询结果,搜索用时 15 毫秒
71.
Asghar?Rahmani Koroush?Soleimannejad Mohammad?Reza?Hafezi Ahmadi Khairollah?AsadollahiEmail author Zahra?khalighi 《Cardiovascular toxicology》2016,16(4):307-315
Previous studies have reported the harmful effects of exposure to phthalic acid (PA) on heart. No studies have reported the effects of prenatal PA exposure on the structure or function of heart. The current study aimed to investigate the effects of prenatal PA exposure on the markers of oxidative stress and cardiac structure in rats’ offspring. Twenty-four pregnant rats were randomly categorized into three groups of control, exposed to 2.5 and 5 % PA. The morphometric properties of coronary arteries, markers of oxidative stress, and NOS activity were measured in offspring rats. By a dose-dependent manner, the body weight (BW), heart weight (HW), and HW/BW of the intervention groups were reduced and their heart rate and blood pressure were conversely increased compared to the control group. Also, the wall thickness, cross-sectional area of the aorta and septal branch of the descending left coronary artery were significantly increased in the intervention group. In addition, PA significantly increased the level of malondialdehyde and decreased the level of superoxide dismutase and glutathione peroxidase, compared to the control group. This study revealed that prenatal exposure of rats to PA causes vascular dysfunction, increasing oxidative stress, and reduction in cardiac nitric oxide synthetase activity among offspring rats. 相似文献
72.
73.
Alireza Khatony Nahid Dehghan Nayery Fazlolaah Ahmadi Hamid Haghani Katri Vehvilainen-Julkunen 《BMC medical education》2009,9(1):41
Background
Information about web-based education outcomes in comparison with a face-to-face format can help researchers and tutors prepare and deliver future web-based or face-to-face courses more efficiently. The aim of this study was to compare the effectiveness of web-based and face-to-face continuing education methods in improving nurses' knowledge about AIDS. 相似文献74.
Mahmoud Motamedi Sanaz Ahmadi Karvigh Mohammad Ali Sahraian Amir Reza Azimi Samira Navardi 《Seizure》2009,18(8):580-582
Lamotrigine is frequently used to manage epilepsy during pregnancy. However, some major and minor birth defects are reported with lamotrigine monotherapy. This study is a case series report on 20 epileptic women who were receiving lamotrigine in their pregnancy. Apart from the normal pregnancies and births, in our study three patients gave birth to healthy twins, two vanished twin syndromes occurred and one patient had abortion. Twin pregnancy in association with lamotrigine therapy has not been clearly described before. Our observational study raises the idea that lamotrigine may induce twin pregnancy but larger studies need to investigate the presence or absence of such association more decently. 相似文献
75.
Hassan Tavakoli Patricia Khashayar Hadi Ahmadi Amoli Khalil Esfandiari Hossein Ashegh Jalal Rezaii Javad Salimi 《The Journal of emergency medicine》2011
Background: Fireworks are the leading cause of injuries such as burns and amputations during the Persian Wednesday Eve Festival (Chaharshanbeh Soori). Objectives: This study was designed to explore the age of the high-risk population, the type of fireworks most frequently causing injury, the pattern of injury, and the frequency of permanent disabilities. Methods: This cohort study was performed by Tehran Emergency Medical Services at different medical centers all around Tehran, Iran, in individuals referred due to firework-related injuries during 1 month surrounding the festival in the year 2007. The following information was extracted from the patients' medical records: demographic data, the type of fireworks causing injury, the pattern and severity of the injury, the pre-hospital and hospital care provided for the patient, and the patient's condition at the time of discharge. In addition, information on the severity of the remaining disability was recorded 8 months after the injury. Results: There were 197 patients enrolled in the study with a mean age of 20.94 ± 11.31 years; the majority of them were male. Fuse-detonated noisemakers and homemade grenades were the most frequent causes of injury. Hand injury was reported in 39.8% of the cases. Amputation and long-term disability were found in 6 and 12 cases, respectively. None of the patients died during the study period. Conclusion: The fireworks used during a Chaharshanbe Soori ceremony were responsible for a considerable number of injuries to different parts of the body, and some of them led to permanent disabilities. 相似文献
76.
Bijan Ahmadi Zahra Sayed Bonakdar Sayyed Mohammad Hashemi Sayyed Mohammad Sadrkabir Mansoor Karimifar 《Rheumatology international》2011,31(1):27-31
Atherosclerosis has a high prevalence in systemic lupus erythematosus (SLE) patients and vascular endothelial dysfunction
is the earliest stage of atherosclerosis. The aim of this study was to evaluate the prevalence of vascular endothelial dysfunction
and its risk factors in SLE patients and to identify its correlation with disease activity, duration and concomitant conditions
in these patients. A total of 84 female SLE patients and 18 healthy young women were included. The vascular endothelial function
was evaluated via ultrasonographic assessment of the brachial artery diameter to determine flow-mediated dilation (FMD) and
post-TNG dilation–FMD gap (PFG) indexes. FMD indexes of one standard deviation lower than mean FMD of the control group were
considered as impaired, and PFG indexes of one standard deviation more than mean PFG of the control group were defined as
impaired. SLE patients had a higher prevalence of impaired FMD than healthy subjects (48.8 vs. 5.5%). The prevalence of impaired
PFG in SLE cases and healthy subjects was 25 and 5.5%, respectively. FMD and PFG impairment did not have any significant correlation
with disease activity, duration, presence of anti-dsDNA, anticardiolipin antibodies, antiphospholipid syndrome and history
of receiving cyclophosphamide pulses. Vascular endothelial dysfunction is very common in SLE patients and no single specific
factor can explain this finding. We recommend the application of brachial artery Doppler ultrasound as a screening test for
detection of early stages of atherosclerosis in SLE patients. 相似文献
77.
Arianeb Mehrabi Hamidreza Fonouni Rezvan Ahmadi Bruno M. Schmied Sascha A. Müller Thilo Welsch Peter Hallscheidt Martin Zeier Jürgen Weitz Jan Schmidt 《Clinical transplantation》2009,23(3):321-328
Abstract: Using lacerated livers for liver transplantation (LTx) can add an option to the extended donor criteria. We present an LTx case using a severely lacerated liver and review of the literature for reported cases. We used a high-grade lacerated liver from a 19-yr-old brain-dead patient caused by traffic accident. The liver had grade IV and II lacerations in the right and left lobe, respectively. Lacerations were managed by sealants, stitching and perihepatic packing. The liver was transplanted to a 49-yr-old man suffering from hepatocellular carcinoma on hepatitis C-induced liver cirrhosis. The two-yr follow-up was uneventful. All published LTx cases using traumatized livers (n = 18) were analyzed. The liver injury ranged from subcapsular hematoma to deep ruptures. Most reported lacerations were in the right lobe, which were managed by digital compression, suturing, electrocautery, and perihepatic packing. The reported complications were primary non- (18%), or poor function, liver abscess, bilioma, and subhepatic hematoma each in one case (5.5%). Six-month graft and patient survival were 71% and 88%, respectively. With meticulous management lacerated livers can be transplanted successfully. Because of complexity of the management, procurement and transplantation should be done by experienced liver surgeons. These organs are marginal grafts and should be offered to selected patients. 相似文献
78.
79.
Four patients with complex cardiac lesions, who underwent successfully a Fontan type of operation are presented, each case representing a particular problem in surgical management. The first exhibited displacement of a trileaflet straddling and overriding left atrioventricular valve in addition to tricuspid atresia, while the second one had unilateral lung perfusion. In the third case, a stenosis had developed near the origin of the right pulmonary artery, and pulmonary vascular resistance could not be determined prior to the definite palliation procedure, whereas the fourth patient presented with stenosis of the left atrioventricular valve. Surgery was planned after detailed evaluation of the morphologic and hemodynamic features by means of echocardiography and cardiac catheterization. Our results illustrate the common tendency to extend the limits for modified Fontan procedures, which also includes revision of the original criteria for selection. 相似文献
80.
Martin Schillinger Markus Exner Schila Sabeti Jasmin Amighi Oswald Wagner Ramazanali Ahmadi Erich Minar 《Journal of endovascular therapy》2004,11(3):229-239
PURPOSE: To examine if excessive in-stent neointimal formation causing a subcritical stenosis may indicate enhanced vascular reactivity in response to injury, thus predicting late cardiovascular events. METHODS: One hundred consecutive patients (64 men; median age 71 years) with high-grade internal carotid artery stenoses (68 asymptomatic, 32 symptomatic) underwent carotid artery stenting (CAS). High-sensitivity C-reactive protein (hs-CRP) was measured before CAS. Patients were monitored with duplex ultrasound for excessive in-stent neointimal formation (flow-compromising lumen diameter reduction >/=50%), critical restenosis (>/=70%), or the occurrence of late major adverse cardiovascular events (MACE) defined as myocardial infarction (MI), stroke, and death occurring later than 30 days poststenting. RESULTS: Over a median 23-month follow-up, excessive neointimal formation was observed in 14 (14%) patients, restenosis in 2 (2%), and 30 late MACE in 25 [25%: 4 MIs, 2 ipsilateral strokes (in the patients with restenosis), 8 contralateral strokes, and 16 cardiovascular deaths]. Cumulative MACE-free survival rates at 6, 12, and 24 months were 92%, 84%, and 77%, respectively. Baseline hs-CRP levels were associated both with neointimal hyperplasia (p=0.024) and MACE (p=0.021). Patients with excessive neointimal formation exhibited a significantly increased adjusted risk for MACE (hazard ratio 3.56, p=0.010). CONCLUSIONS: Excessive in-stent neointimal formation after CAS indicates an increased risk for late MACE, potentially reflecting a state of exaggerated vascular reactivity in response to injury. Inflammation, which is associated both with neointimal hyperplasia and MACE, seems a common characteristic of different vascular pathologies. 相似文献